LACK OF ACTIVITIES OF AMIKACIN AND SULFAMETHOXAZOLE AGAINST MYCOBACTERIUM-AVIUM-INTRACELLULARE
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香港中文大學研究人員

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摘要Twenty clinical isolates of Mycobacterium avium-intracellulare were tested with amikacin and sulphamethoxazole for in-vitro susceptibilities. The MICs and MBCs of the former drug ranged from 8 to >64 mg/L (median MIC: 64 mg/L, median MBC: >64 mg/L). The MICs and MBCs of the latter drug were found to be >256 mg/L. Each of eight patients with invasive pulmonary disease due to these organisms was treated with amikacin for six months and with cotrimoxazole (sulphamethoxazole-trimethoprim) for one year. Only one patient had sustained bacteriological conversion. Three patients showed a transient reduction of bacillary load during the period of amikacin administration. The rest all failed to show response. Thus sulphamethoxazole was found to have no activity against Mycobacterium avium-intracellulare, and amikacin has doubtful activity when used alone in treatment of M. avium-intracellulare infection.
著者YEW WW, TAM CM, CHAN CY, LI MSK, CHENG AFB
期刊名稱International Journal of Clinical Pharmacology Research
出版年份1993
月份1
日期1
卷號13
期次2
出版社BIOSCIENCE EDIPRINT INC
頁次65 - 68
國際標準期刊號0251-1649
語言英式英語
Web of Science 學科類別Pharmacology & Pharmacy

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