CGRP-IMMUNOREACTIVITY IN MERKEL CELLS AND NONMYELINATED NERVE PLEXUSES OF DOG SKIN
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AbstractIN dog skin Merkel cells, calcitonin gene-related peptide (CGRP) immunoreactivity was consistently encountered at the subcellular dense-core granule region. The immunogold particles used as a marker for CGRP, were located specifically in and around the dense-core granules. They were also found in the surrounding cytoplasm close to the dense-core granules. Nerve terminals supplying the Merkel cell were CGRP-negative. CGRP-immunoreactive nonmyelinated nerve fibres were also found in the same specimen. These nonmyelinated nerve fibres were ensheathed by Schwann cell cytoplasm. The gold particles were only located in the dense-core granules of the axis cylinders. It is concluded that a CGRP-like substance predominantly accumulates in the dense-core granules of dog Merkel cells as well as in cutaneous nonmyelinated fibres.
All Author(s) ListCHEW SBC, LEUNG PY
Journal nameNeuroReport
Year1993
Month4
Day1
Volume Number4
Issue Number4
PublisherRAPID SCIENCE PUBLISHERS
Pages457 - 459
ISSN0959-4965
eISSN1473-558X
LanguagesEnglish-United Kingdom
KeywordsCGRP; CUTANEOUS NERVE; EM IMMUNOCYTOCHEMISTRY; MERKEL CELL
Web of Science Subject CategoriesNeurosciences; NEUROSCIENCES; Neurosciences & Neurology

Last updated on 2021-17-01 at 00:38