TRICHOSANTHIN AS AN ABORTIFACIENT FOR TERMINATING EARLY-PREGNANCY IN MICE
Publication in refereed journal


全文

引用次數

其它資訊
摘要Objective-To test trichosanthin-a basic protein from Trichosanthes kirilowii-as abortifacient, and effect on subsequent pregnancy. Methods-Female mice, on day 1, 2, or 3 of pregnancy, given 0.10, 0.15, 0.20, or 0.25 mg/25 g body wt., intraperitoneally. Animals killed on day 11 for assessment of abortion, or day 4 for examination of embryos. Subsequent pregnancy was tested after 20 days in mice that had aborted completely. Results-With 0.20-0.25 mg/25 g, 64-80% aborted. At day 4, pre-implantation development was disturbed, many still being morulae (in the oviduct). Subsequent pregnancies and offspring were entirely normal. Conclusions-Trichosanthin, long used to effect abortion in humans in China, has congruent effects on ICR laboratory mice.
著者CHAN WY, NG TB, YEUNG HW
期刊名稱INTERNATIONAL JOURNAL OF FERTILITY
詳細描述U.S. International Foundation for Studies in Reproduction, Inc., Scandinavian Association for Studies in Fertility, Falloppins International Society,
出版年份1993
月份3
日期1
卷號38
期次2
出版社MEDICAL SCIENCE PUBLISHING INT INC
頁次99 - 107
國際標準期刊號0020-725X
語言英式英語
關鍵詞ABORTIFACIENTS; ANIMAL STUDIES; TRICHOSANTHIN
Web of Science 學科類別Obstetrics & Gynecology

上次更新時間 2020-13-10 於 02:45