PETHIDINE PHARMACOKINETICS AFTER INTRAMUSCULAR DOSE - A COMPARISON IN CAUCASIAN, CHINESE AND NEPALESE PATIENTS
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AbstractThe pharmacokinetics of pethidine after a single intramuscular injection were studied in 30 male patients of Caucasian, Chinese and Nepalese extraction. There were no significant differences between the three ethnic groups in the mean time for maximum absorption (t(max)) and peak plasma concentration (C(max)) of pethidine. The mean (+/- S.D.) elimination half life (t1/2) of pethidine was shorter in Caucasians (4.5 +/- 1.3 h) compared with Nepalese (6.3 +/- 1.6 h) and Chinese (8.1 +/- 3.1 h) (p < 0.01). The plasma clearance of pethidine was greater in Caucasians (14.2 +/- 4.8 ml.min-1.kg-1) than in Nepalese (12.6 +/- 2.9 ml.min-1.kg-1) and Chinese (10.0 +/- 2.9 ml.min-1.kg-1) (p < 0.05); yet the apparent renal clearance was similar (64.1 +/- 22.9, 86.7 +/- 44.5 and 61.4 +/- 30.1 ml.min-1, respectively, for the Chinese (n = 6), Caucasian (n = 6) and Nepalese (n = 9) patients). No apparent ethnic differences were found in the t(max) and C(max) of norpethidine which emerged as the major metabolite in the plasma in the three races. An apparently higher area under plasma concentration-time curve (AUC(and)infinity) and longer elimination t1/2 of the metabolite were observed in the two Asian patient groups. It appears that both the Chinese and Indian groups did not eliminate pethidine as effectively as the Caucasians after a single intramuscular injection, which may be the result of interethnic variability in the metabolism of pethidine. Caution may be required on multiple dosing of pethidine in Asian patients due to the possible accumulation of the parent drug and its toxic metabolite, norpethidine.
All Author(s) ListHOUGHTON IT, CHAN K, WONG YC, AUN CST, LAU OW, LOWE DM
Journal nameMETHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY
Year1992
Month7
Day1
Volume Number14
Issue Number6
PublisherJ R PROUS SA
Pages451 - 458
ISSN0379-0355
LanguagesEnglish-United Kingdom
KeywordsCAUCASIAN; CHINESE; INTRAMUSCULAR PETHIDINE; NEPALESE; PHARMACOKINETICS
Web of Science Subject CategoriesPharmacology & Pharmacy; PHARMACOLOGY & PHARMACY

Last updated on 2020-12-08 at 02:08