A NEW BIOFILM STORY IN BILIARY-TRACT INFECTION
Publication in refereed journal

香港中文大學研究人員

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摘要Acute cholangitis is commonly caused by biliary obstruction due to gallstones blocking the bile ducts and to malignancies of the biliary and pancreatic system. The pathogenesis of brown pigment gallstones, blockage of biliary stents, and biliary parasitic infestation are related to the formation of bacterial biofilms. Biliary pathogens, such as Escherichia coli and other enteric organisms, attach themselves to the surface of an ulcerated biliary mucosa or implanted biomaterial to form a bacterial biofilm. Some of these bacteria produce enzymes (beta-glucuronidase and phospholipid A1) and glycocalyx material that aid colonization and infestation. Crystals of calcium bilirubinate and other biliary sediments accumulate around the bacterial microcolonies and glycoproteins, forming adherent bacterial biofilms. The thick and often calcified biofilms obstruct the normal bile flow and lead to cholangitis.
著者SUNG JY, LEUNG JWC, COSTERTON JW
期刊名稱International Biodeterioration and Biodegradation
出版年份1992
月份1
日期1
卷號30
期次2-3
出版社ELSEVIER SCI LTD
頁次155 - 165
國際標準期刊號0964-8305
電子國際標準期刊號1879-0208
語言英式英語
Web of Science 學科類別Biotechnology & Applied Microbiology; BIOTECHNOLOGY & APPLIED MICROBIOLOGY; Environmental Sciences; ENVIRONMENTAL SCIENCES; Environmental Sciences & Ecology

上次更新時間 2020-28-11 於 01:17