A NEW BIOFILM STORY IN BILIARY-TRACT INFECTION
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AbstractAcute cholangitis is commonly caused by biliary obstruction due to gallstones blocking the bile ducts and to malignancies of the biliary and pancreatic system. The pathogenesis of brown pigment gallstones, blockage of biliary stents, and biliary parasitic infestation are related to the formation of bacterial biofilms. Biliary pathogens, such as Escherichia coli and other enteric organisms, attach themselves to the surface of an ulcerated biliary mucosa or implanted biomaterial to form a bacterial biofilm. Some of these bacteria produce enzymes (beta-glucuronidase and phospholipid A1) and glycocalyx material that aid colonization and infestation. Crystals of calcium bilirubinate and other biliary sediments accumulate around the bacterial microcolonies and glycoproteins, forming adherent bacterial biofilms. The thick and often calcified biofilms obstruct the normal bile flow and lead to cholangitis.
All Author(s) ListSUNG JY, LEUNG JWC, COSTERTON JW
Journal nameInternational Biodeterioration and Biodegradation
Year1992
Month1
Day1
Volume Number30
Issue Number2-3
PublisherELSEVIER SCI LTD
Pages155 - 165
ISSN0964-8305
eISSN1879-0208
LanguagesEnglish-United Kingdom
Web of Science Subject CategoriesBiotechnology & Applied Microbiology; BIOTECHNOLOGY & APPLIED MICROBIOLOGY; Environmental Sciences; ENVIRONMENTAL SCIENCES; Environmental Sciences & Ecology

Last updated on 2020-28-11 at 01:17