EFFECT OF BILIARY OBSTRUCTION ON THE HEPATIC EXCRETION OF IMIPENEM-CILASTATIN
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AbstractThe biliary excretion of imipenem-cilastatin studied by endoscopic cannulation of the common bile duct in patients with complete obstruction and in a group without obstruction showed that despite a 24-h prophylaxis, the bile obtained from patients with obstruction immediately after cannulation contained neither imipenem nor cilastatin, while there were 2 and 5% of peak concentrations in serum for imipenem and cilastatin, respectively, in the bile from patients without obstruction. Biliary excretion of both compounds increased rapidly after decompression, reaching a maximum of 15% of peak levels in serum within 2 h. Twenty-four hours after drainage, the biliary excretion of the drugs further improved. We conclude that since biliary obstruction impairs excretion of antibiotics, drainage is necessary for the control of sepsis in obstructed cholangitis.
All Author(s) ListLEUNG JWC, CHAN CY, LAI CW, KO TC, CHENG AFB, FRENCH GL
Journal nameAntimicrobial Agents and Chemotherapy
Year1992
Month9
Day1
Volume Number36
Issue Number9
PublisherAMER SOC MICROBIOLOGY
Pages2057 - 2060
ISSN0066-4804
eISSN1098-6596
LanguagesEnglish-United Kingdom
Web of Science Subject CategoriesMicrobiology; MICROBIOLOGY; Pharmacology & Pharmacy; PHARMACOLOGY & PHARMACY

Last updated on 2021-23-01 at 02:37