FATAL ADULT HENOCH-SCHONLEIN PURPURA DUE TO SMALL INTESTINAL INFARCTION
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AbstractA 57-year-old woman presented with classical symptoms of Henoch-Schonlein purpura including arthralgia, abdominal pain, palpable purpuric rash and abnormalities of the urinary sediments. The clinical course was subsequently complicated by severe paralytic ileus leading to respiratory embarrassment. Laparotomy confirmed patchy areas of small bowel infarction due to necrotizing vasculitis. Skin biopsy revealed extensive leukocytoclastic vasculitis with granular deposits of IgA in the blood vessels. Anti-neutrophil cytoplasmic autoantibodies (ANCA) were not detectable. The patient continued to deteriorate despite bowel resection, intensive immunosuppressive therapy and plasma exchange, and eventually died. Gastrointestinal involvement in adult Henoch-Schonlein purpura has previously been reported to have a favourable clinical course. However, our case illustrates the rare but lethal complication of intestinal infarction in patients who fail to respond to conservative treatment.
All Author(s) ListCHAN JCN, LI PKT, LAI FM, LAI KN
Journal nameJournal of Internal Medicine
Year1992
Month8
Day1
Volume Number232
Issue Number2
PublisherBLACKWELL SCIENCE LTD
Pages181 - 184
ISSN0954-6820
LanguagesEnglish-United Kingdom
KeywordsHENOCH-SCHONLEIN PURPURA; SMALL INTESTINAL INFARCTION
Web of Science Subject CategoriesGeneral & Internal Medicine; Medicine, General & Internal; MEDICINE, GENERAL & INTERNAL

Last updated on 2020-16-10 at 02:34