ACTIVATION OF PROTEIN-KINASE-C ATTENUATES THE CYCLIC-GMP RESPONSES TO C-TYPE NATRIURETIC PEPTIDE IN CULTURED MOUSE ASTROCYTES
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香港中文大學研究人員

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摘要C-type natriuretic peptide (CNP), a recently discovered natriuretic peptide, has a potent stimulatory effect on cyclic GMP (cGMP) formation in cultured mouse astrocytes. Pretreatment of astrocytes with phorbol 12-myristate 13-acetate (PMA), an activator of protein kinase C (PKC), attenuated CNP-induced cGMP responses in a dose-dependent manner, with a half-maximal inhibitory concentration of 6 nM, whereas the inactive phorbol ester analog, 4-alpha-phorbol 12,13-didecanoate, was without effect. In the presence of staurosporine, a PKC inhibitor, the inhibitory effect of PMA on CNP-stimulated cGMP production was reversed. These results suggest that PKC is an inhibitory modulator of CNP-stimulated cGMP responses in astrocytes and that CNP may interact with neuropeptides which stimulate PKC.
著者YEUNG VTF, HO SKS, COCKRAM CS, LEE CM, NICHOLLS MG
期刊名稱FEBS Letters
出版年份1992
月份8
日期24
卷號308
期次3
出版社ELSEVIER SCIENCE BV
頁次301 - 304
國際標準期刊號0014-5793
電子國際標準期刊號1873-3468
語言英式英語
關鍵詞ASTROCYTE; C-TYPE NATRIURETIC PEPTIDE; CYCLIC GMP; PROTEIN KINASE-C
Web of Science 學科類別Biochemistry & Molecular Biology; BIOCHEMISTRY & MOLECULAR BIOLOGY; Biophysics; BIOPHYSICS; Cell Biology; CELL BIOLOGY

上次更新時間 2020-18-11 於 01:34