SUSCEPTIBILITY TO IDDM IN A CHINESE POPULATION - ROLE OF HLA CLASS-II ALLELES
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摘要MHC associations with IDDM in a Chinese population were studied to investigate genetic susceptibility to th disorder. The frequency of HLA-DR3 was significantly higher in the diabetic patients (19/49 [38.7%] vs. control subjects, 11/105 [10.5%], P(c) < 1.3 x 10(-3), RR = 5.3 [Cl 2.3-12.1]), whereas DR4 was not (11/49 (22.4%] vs. 28/105 [26.7%], NS). The frequency of DR3/4 heterozygosity was higher in the diabetic patients (6/49 (12.2%] vs. control subjects, 0/105 [0%], P = 1.7 x 10(-3), RR = 31.5 [Cl 3.8-263.6]). The frequency of DR3/9 heterozygosity also was higher in the diabetic patients (6/49 [12.2%] vs. control subjects, 2/105 [1.9%], P = 0.03, RR = 6.2 [Cl 3.0-12.7]). No significant associations were noted between DQB1 alleles and IDDM. Among DR4-positive subjects, the frequency of the DQB1 allele DQB1*0302 was higher in the diabetic patients (10/11 [90.0%] vs. control subjects, 12/24 [50%], P(c) < 0.05, RR = 7.0 [Cl 1.3-38.0]), and the frequency of DQB1*0401 was significantly lower in the diabetic patients (2/11 [18.2%] vs. control subjects, 16/24 [66.7%], P(c) = 0.04, RR = 0.1 [Cl 0.02-0.46]). No DR4 subtype was associated significantly with IDDM. The frequency of DQA1*0501, a DQA1 allele, was higher in diabetic patients (22/41 [53.7%] vs. control subjects, 20/95 [21.1%], P(c) < 3 X 10(-3), RR = 4.3 [Cl 2.0-9.3]). The frequency of DQA1*0301, which has been associated consistently with IDDM in other ethnic groups, was not significantly higher in the diabetic patients in this study (27/41 [65.9%] vs. control subjects 53/95 [55.8%], NS). The frequency of the DR4 haplotype DRB1*0405-DQA1*0301-DQB1*0401 was lower among DR4-positive diabetic patients (2/10 [20%] vs. DR4-positive control subjects, 12/21 [57.1%], NS), in direct contrast with Japanese populations. These results suggest that If DQB1 and DQA1 alleles determine IDDM susceptibility, other MHC factors must modify their effect.
著者PENNY MA, JENKINS D, MIJOVIC CH, JACOBS KH, CAVAN DA, YEUNG VTF, COCKRAM CS, HAWKINS BR, FLETCHER JA, BARNETT AH
期刊名稱Diabetes
出版年份1992
月份8
日期1
卷號41
期次8
出版社AMER DIABETES ASSOC
頁次914 - 919
國際標準期刊號0012-1797
電子國際標準期刊號1939-327X
語言英式英語
Web of Science 學科類別Endocrinology & Metabolism; ENDOCRINOLOGY & METABOLISM

上次更新時間 2021-08-01 於 00:47