C-TYPE NATRIURETIC PEPTIDE IS A POTENT STIMULATOR OF CYCLIC-GMP PRODUCTION IN CULTURED MOUSE ASTROCYTES
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摘要The effect of C-type natriuretic peptide (CNP), a novel member of the natriuretic peptide family, on cyclic GMP (cGMP) generation was studied in primary cultures of mouse astrocytes. CNP stimulated cGMP production by mouse astrocytes in a dose-dependent fashion, with an EC50 of 32 nM and a maximal stimulatory concentration of > 1-mu-M, which induced a rise of cGMP level from a baseline of 1.0 +/- 0.1 pmol/mg of protein to 196.2 +/- 22.0 pmol/mg of protein. Compared with our previously reported atrial and brain natriuretic peptide-induced cGMP responses, CNP had a lower EC50 and was 10-20 times more efficacious in its maximal effect on cGMP stimulation. These data lend support to the concept of a significant role of CNP in neuromodulation/neurotransmission.
著者YEUNG VTF, HO SKS, COCKRAM CS, LEE CM, NICHOLLS MG
期刊名稱Journal of Neurochemistry
出版年份1992
月份8
日期1
卷號59
期次2
出版社LIPPINCOTT-RAVEN PUBL
頁次762 - 764
國際標準期刊號0022-3042
語言英式英語
關鍵詞ASTROCYTES; C-TYPE NATRIURETIC PEPTIDE; CYCLIC GMP
Web of Science 學科類別Biochemistry & Molecular Biology; BIOCHEMISTRY & MOLECULAR BIOLOGY; Neurosciences; NEUROSCIENCES; Neurosciences & Neurology

上次更新時間 2021-19-01 於 01:57