C-TYPE NATRIURETIC PEPTIDE IS A POTENT STIMULATOR OF CYCLIC-GMP PRODUCTION IN CULTURED MOUSE ASTROCYTES
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AbstractThe effect of C-type natriuretic peptide (CNP), a novel member of the natriuretic peptide family, on cyclic GMP (cGMP) generation was studied in primary cultures of mouse astrocytes. CNP stimulated cGMP production by mouse astrocytes in a dose-dependent fashion, with an EC50 of 32 nM and a maximal stimulatory concentration of > 1-mu-M, which induced a rise of cGMP level from a baseline of 1.0 +/- 0.1 pmol/mg of protein to 196.2 +/- 22.0 pmol/mg of protein. Compared with our previously reported atrial and brain natriuretic peptide-induced cGMP responses, CNP had a lower EC50 and was 10-20 times more efficacious in its maximal effect on cGMP stimulation. These data lend support to the concept of a significant role of CNP in neuromodulation/neurotransmission.
All Author(s) ListYEUNG VTF, HO SKS, COCKRAM CS, LEE CM, NICHOLLS MG
Journal nameJournal of Neurochemistry
Year1992
Month8
Day1
Volume Number59
Issue Number2
PublisherLIPPINCOTT-RAVEN PUBL
Pages762 - 764
ISSN0022-3042
LanguagesEnglish-United Kingdom
KeywordsASTROCYTES; C-TYPE NATRIURETIC PEPTIDE; CYCLIC GMP
Web of Science Subject CategoriesBiochemistry & Molecular Biology; BIOCHEMISTRY & MOLECULAR BIOLOGY; Neurosciences; NEUROSCIENCES; Neurosciences & Neurology

Last updated on 2020-23-11 at 00:27