CRESCENTIC GLOMERULONEPHRITIS RELATED TO HEPATITIS-B VIRUS
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AbstractCrescentic glomerulonephritis was diagnosed in two chronic hepatitis B surface antigen carriers. In all three biopsies performed, hepatitis B e antigen was found in glomerular capillary tufts. The first patient presented with nephrotic syndrome and acute renal failure. The glomerular pathology revealed crescentic glomerulonephritis with endocapillary proliferation, and she recovered spontaneously with normal renal function over the following 6 mo despite a persistent hepatitis B surface antigenemia. The other patient presented with nephrotic syndrome and normal renal function. Hepatitis B virus-related membranous nephropathy was diagnosed on the first biopsy, and he did well on symptomatic treatment for 20 mo. The nephrotic syndrome recurred and subsequently he developed acute renal failure a month following interferon treatment. The repeated biopsy revealed a crescentic glomerulonephritis that was associated with mixed membranous and membranoproliferative glomerulopathies. This patient responded to immunosuppression and plasma exchange with residual impairment of renal function. He has been stable after 18 mo follow-up.
All Author(s) ListLAI FMM, LI PKT, SUEN MWM, LUI SF, LAI KN
Journal nameModern Pathology
Year1992
Month5
Day1
Volume Number5
Issue Number3
PublisherWILLIAMS & WILKINS
Pages262 - 267
ISSN0893-3952
eISSN1530-0285
LanguagesEnglish-United Kingdom
KeywordsCRESCENTIC GLOMERULONEPHRITIS; HEPATITIS-B E ANTIGEN; HEPATITIS-B SURFACE ANTIGENEMIA; IMMUNE COMPLEXES
Web of Science Subject CategoriesPathology; PATHOLOGY

Last updated on 2020-29-05 at 00:42