ASCENDING INFECTION OF THE BILIARY-TRACT AFTER SURGICAL SPHINCTEROTOMY AND BILIARY STENTING
Publication in refereed journal


Times Cited
Web of Science81WOS source URL (as at 21/11/2020) Click here for the latest count
Altmetrics Information
.

Other information
AbstractIt has been widely accepted that there is an ascending route of bacterial infection of the biliary tract but there is a lack of direct evidence. This hypothesis was tested in an animal experiment using the cat as an animal model. The implantation of biliary stents and surgical sphincterotomy were performed in these animals, with sham controls. Stents bypassing the sphincter of Oddi with the tip in the duodenal lumen were colonized by duodenal micro-organisms and the biliary tract was heavily contaminated. Blockage of these stents resulted in biliary obstruction. Stents implanted within the common bile duct, proximal to the sphincter were largely unaffected by biofilm formation. After surgical sphincterotomy the biliary tract was also contaminated but, in the absence of obstruction, the animals did not develop any symptoms. It was concluded that ascending infection by duodenal biliary reflux, via the sphincter of Oddi, is an important route of infection in the biliary system.
All Author(s) ListSUNG JY, LEUNG JWC, SHAFFER EA, LAM K, OLSON ME, COSTERTON JW
Journal nameJournal of Gastroenterology and Hepatology
Year1992
Month5
Day1
Volume Number7
Issue Number3
PublisherBLACKWELL SCIENCE
Pages240 - 245
ISSN0815-9319
eISSN1440-1746
LanguagesEnglish-United Kingdom
KeywordsBACTERIA; BILIARY STENT; BIOFILM; SPHINCTEROTOMY
Web of Science Subject CategoriesGastroenterology & Hepatology; GASTROENTEROLOGY & HEPATOLOGY

Last updated on 2020-22-11 at 01:45