FOLATE CONCENTRATION IN CHINESE PSYCHIATRIC OUTPATIENTS ON LONG-TERM LITHIUM TREATMENT
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AbstractAmong 46 Chinese and mostly manic-depressive (85%) outpatients attending a lithium clinic in Hong Kong, virtually no patients had low serum (0%) or erythrocyte (2%) folate. Their mean folate levels did not differ from lithium-free outpatients. Although serum folate correlated negatively with lithium dose (P < 0.002) and serum level (P < 0.01), lithium treatment probably did not by itself cause low folate. Folate level was not related to diagnosis, duration of mental illness, other drug usage or spot affective morbidity. Patients with a good response to lithium in the previous one year had a higher mean serum folate level than those with unsatisfactory response (P < 0.05). These data suggest that folate deficiency is uncommon among Chinese psychiatric outpatients, but support recent evidence that folate at high concentrations enhances lithium prophylaxis.
All Author(s) ListLEE S, CHOW CC, SHEK CC, WING YK, CHEN CN
Journal nameJournal of Affective Disorders
Year1992
Month4
Day1
Volume Number24
Issue Number4
PublisherELSEVIER SCIENCE BV
Pages265 - 270
ISSN0165-0327
eISSN1573-2517
LanguagesEnglish-United Kingdom
KeywordsCHINESE; FOLATE; LITHIUM
Web of Science Subject CategoriesClinical Neurology; CLINICAL NEUROLOGY; Neurosciences & Neurology; Psychiatry; PSYCHIATRY, SCI; PSYCHIATRY, SSCI

Last updated on 2020-22-10 at 00:33