REDUCTION OF CELLULAR-DAMAGE INDUCED BY CEREBRAL-ISCHEMIA IN RATS
Publication in refereed journal

香港中文大學研究人員

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其它資訊
摘要A model of incomplete cerebral ischemia involving bilateral ligation of the common carotid arteries in rats, was used to examine the potential of a Chinese herbal preparation and of nifedipine to reduce cell damage following cerebral ischemia. The herbal preparation contained ginsengosides and extracts of Panax notoginseng, Ligusticum chuanxiong Hort., Carthamus tinctorius L. and Salvia militorrhiza Bge. Histological evidence of cell damage and the formation of peroxidation products were both reduced in rats pretreated with the herbal preparation or with nifedipine. It has been suggested that the free radical reaction is involved in tissue damage, particularly in the pathological neurocyte injury of cerebral ishemia. The results show that in this model of incomplete cerebral ischemia, the degree of lipid peroxidation can be lowered by the pretreatment with Chinese herbs containing ginsengosides or with nifedipine. These drugs maybe beneficial in the treatment of cerebral ischemia in humans.
著者LEUNG AWN, MO ZX, ZHENG YS
期刊名稱Neurochemical Research
出版年份1991
月份6
日期1
卷號16
期次6
出版社PLENUM PUBL CORP
頁次687 - 692
國際標準期刊號0364-3190
語言英式英語
關鍵詞CEREBRAL ISCHEMIA; CHINESE HERBAL GINSENGOSIDES; MALONDIALDEHYDE; NIFEDIPINE
Web of Science 學科類別Biochemistry & Molecular Biology; BIOCHEMISTRY & MOLECULAR BIOLOGY; Neurosciences; NEUROSCIENCES; Neurosciences & Neurology

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