LYMPHOCYTE-T ACTIVATION IN PATIENTS WITH ACTIVE TUBERCULOSIS
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AbstractSoluble interleukin-2 receptor (sIL-2R) is a marker of T lymphocyte activation. We measured the amount of serum sIL-2R in 35 patients with active tuberculosis before the initiation of antituberculous treatment. Twenty had pulmonary parenchymal lesion, 8 had tuberculous pleural effusion, and 7 had tuberculous lymphadenitis. The serum sIL-2R values were markedly elevated in patients with pulmonary tuberculosis (parenchymal lesion and pleural effusion) compared with patients with tuberculous lymphadenitis (2,612 +/- 536 versus 538 +/- 121 U/ml, p = 0.023), old, inactive tuberculosis (335 +/- 23 U/ml, p = 0.001), and normal control subjects (376 +/- 38 U/ml, p = 0.001). No significant differences was found between patients with parenchymal lesion and those with tuberculous pleural effusion. There was a positive correlation between serum sIL-2R values and the extent of disease on chest radiograph (r = 0.58, p < 0.001). We conclude that the amount of sIL-2R may be a useful marker of disease activity and extent of involvement in patients with active tuberculous lesions.
All Author(s) ListCHAN CHS, LAI KN, LEUNG JCK, LAI CKW
Journal nameAMERICAN REVIEW OF RESPIRATORY DISEASE
Year1991
Month8
Day1
Volume Number144
Issue Number2
PublisherAMER LUNG ASSOC
Pages458 - 460
ISSN0003-0805
LanguagesEnglish-United Kingdom
Web of Science Subject CategoriesRespiratory System

Last updated on 2020-02-06 at 00:46