LIGHT CHAIN RATIOS OF SERUM IMMUNOGLOBULINS IN DISEASE
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摘要We have determined the individual kappa (kappa)/ lambda (lambda) ratios of serum IgG, IgA, and IgM in normal subjects and patients with rheumatoid arthritis, systemic lupus erythematosus, hepatic cirrhosis and IgA nephropathy - 40 in each group. Serum samples were first screened by agarose electrophoresis to exclude paraproteinaemia. Concentrations of IgG, IgA, and IgM were determined by enzyme-linked immunosorbent assay (ELISA). The kappa and lambda-chain concentrations of each immunoglobulin class were assayed by an ELISA method first developed by us for the determination of kappa/lambda ratios. Our results showed that kappa/lambda ratios of serum IgA and IgM were significantly different from that of IgG in normal subjects and the 4 groups of patients studied (p < 0.01). The kappa/lambda ratios of individual immunoglobulins in patients with rheumatoid arthritis, systemic lupus erythematosus and liver cirrhosis were similar to those of normal subjects. However, patients with IgA nephropathy displayed a distinctly lower IgA kappa/lambda ratio, suggesting a unique antibody response in the immunopathogenesis of this disease.
著者LAM CWK, CHUI SH, LEUNG NWY, LI EKM, LAI KN
期刊名稱Clinical Biochemistry
出版年份1991
月份6
日期1
卷號24
期次3
出版社PERGAMON-ELSEVIER SCIENCE LTD
頁次283 - 287
國際標準期刊號0009-9120
電子國際標準期刊號1873-2933
語言英式英語
關鍵詞ELISA; IGA NEPHROPATHY; IMMUNE-COMPLEX DISEASE; LIGHT CHAIN RATIOS; SERUM IMMUNOGLOBULINS
Web of Science 學科類別Medical Laboratory Technology; MEDICAL LABORATORY TECHNOLOGY

上次更新時間 2020-26-10 於 00:50