HYPERTENSION, LIPOPROTEIN(A), AND APOLIPOPROTEIN-A-I AS RISK-FACTORS FOR STROKE IN THE CHINESE
Publication in refereed journal


引用次數
替代計量分析
.

其它資訊
摘要We analyzed the serum concentrations of lipids and lipoproteins and the prevalence of other risk factors in a case-control study of 304 consecutive Chinese patients with acute stroke (classified as cerebral infarction, lacunar infarction, or intracerebral hemorrhage) and 304 age- and sex-matched controls. For all strokes we identified the following risk factors: a history of ischemic heart disease, diabetes mellitus, or hypertension; the presence of atrial fibrillation or left ventricular hypertrophy; a glycosylated hemoglobin A1 concentration of > 9.1%; a fasting plasma glucose concentration 3 months after stroke of > 6.0 mmol/l; a serum triglyceride concentration 3 months after stroke of > 2.1 mmol/l; and a serum lipoprotein (a) concentration of > 29.2 mg/dl. We found the following protective factors: a serum high density lipoprotein-cholesterol concentration of > 1.59 mmol/l and a serum apolipoprotein A-I concentration of greater-than-or-equal-to 106 mg/dl. The patterns of risk factors differed among the three stroke subtypes. When significant risk factors were entered into a multiple logistic regression model, we found a history of hypertension, a high serum lipoprotein(a) concentration, and a low apolipoprotein A-I concentration to be independent risk factors for all strokes. The attributable risk for hypertension was estimated to be 24% in patients aged greater-than-or-equal-to 60 years. In this population, in which cerebrovascular diseases are the third commonest cause of mortality, identification of risk factors will allow further studies in risk factor modification for the prevention of stroke.
著者WOO J, LAU E, LAM CWK, KAY R, TEOH R, WONG HY, PRALL WY, KREEL L, NICHOLLS MG
期刊名稱Stroke
出版年份1991
月份2
日期1
卷號22
期次2
出版社AMER HEART ASSOC
頁次203 - 208
國際標準期刊號0039-2499
電子國際標準期刊號1524-4628
語言英式英語
關鍵詞INTRACEREBRAL HEMORRHAGE; LACUNAR INFARCTION; RISK FACTORS
Web of Science 學科類別Cardiovascular System & Cardiology; Clinical Neurology; CLINICAL NEUROLOGY; Neurosciences & Neurology; Peripheral Vascular Disease; PERIPHERAL VASCULAR DISEASE

上次更新時間 2020-20-10 於 02:59