DISPOSITION OF PROPOFOL INFUSIONS FOR CESAREAN-SECTION
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摘要The disposition of propofol was studied in women undergoing elective Caesarean section. Indices of maternal recovery and neonatal assessment were correlated with venous concentrations of propofol. After induction of anaesthesia with propofol 2.0 mg.kg-1, ten patients received propofol 6 mg.kg-1.hr-1 with nitrous oxide 50 per cent in oxygen (low group) and nine were given propofol 9 mg.kg-1.hr-1 with oxygen 100 per cent (high group). Pharmacokinetic variables were similar between the groups. The mean +/- SD Vss = 2.38 +/- 1.16 L . kg-1, Cl = 39.2 +/- 9.75 ml.min-1.kg-1 and T1[2-beta = 126 +/- 68.7 min. At the time of delivery (8-16 min), the concentration of propofol ranged from 1.91-3.82-mu-g.ml-1 in the maternal vein (MV), 1.00-2.00-mu-g.ml-1 in the umbilical vein (UV) and 0.53-1.66-mu-g.ml-1 in the umbilical artery (UA). Neonates with high UV concentrations of propofol at delivery had lower neurologic and adaptive capacity scores 15 minutes later. The concentrations of propofol were similar between groups during the infusion but they declined at a faster rate in the low group postoperatively. Maternal recovery times did not depend on the total dose of propofol but the concentration of propofol at the time of eye opening was greater in the high group than the low group (1.74 +/- 0.51 vs 1.24 +/- 0.32-mu-g.ml-1, P <0.01). The rapid placental transfer of propofol during Caesarean section requires propofol infusions to be given cautiously, especially when induction to delivery times are long.
著者GIN T, YAU G, CHAN K, GREGORY MA, OH TE
期刊名稱Canadian Journal of Anesthesia / Journal canadien d'anesthésie
出版年份1991
月份1
日期1
卷號38
期次1
出版社CANADIAN ANAESTHETISTS SOC INC
頁次31 - 36
國際標準期刊號0832-610X
電子國際標準期刊號1496-8975
語言英式英語
關鍵詞ANESTHESIA; ANESTHETIC TECHNIQUES; ANESTHETICS; DRUG TRANSFER; INTRAVENOUS; OBSTETRIC; PLACENTA; PROPOFOL; RECOVERY
Web of Science 學科類別Anesthesiology

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