Antiproliferative effect of chlorophyllin derived from a traditional Chinese medicine Bombyx mori excreta on human breast cancer MCF-7 cells
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AbstractChlorophyllin (CHL) is the sodium-copper salts of chlorophyll derivatives. In this study, the CHL was derived from a traditional Chinese medicine, the Bombyx mori excreta. The CHL, at concentrations 25-400 mug/ml, reduced the proliferation of HL-60, K-562, S-180, and MCF-7 cells by 8.2-95.7% after 72 h of incubation. The CHL also accumulated G2/M cells and induced apoptosis in the MCF-7 cells. Furthermore, the breast carcinoma cells exhibited lower cyclin D1 and cyclin E levels but higher cyclin B1 level after incubation with the CHL showing that these cyclin changes may be important for the antiproliferative effect of the CHL.
All Author(s) ListChiu LCM, Kong CKL, Ooi VEC
Journal nameInternational Journal of Oncology
Year2003
Month9
Day1
Volume Number23
Issue Number3
PublisherPROFESSOR D A SPANDIDOS
Pages729 - 735
ISSN1019-6439
eISSN1791-2423
LanguagesEnglish-United Kingdom
Keywordsantiproliferation; apoptosis; cell cycle; chlorophyllin; cyclins
Web of Science Subject CategoriesOncology; ONCOLOGY

Last updated on 2020-30-06 at 02:30