Formation of composite crystals by precipitation in supercritical CO2
Publication in refereed journal

香港中文大學研究人員

引用次數
替代計量分析
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其它資訊
摘要Acetaminophen (A) and p-acetoxyacetanilide (PAA) were used as model drug substances to study purification and coformulation of structurally similar molecules by crystallization from supercritical CO2. Incorporation of PAA into the crystal structure of A was defined by the mutual solubility of crystals of both molecules according to their different solvent-solute interactions, by the thermodynamics of the A-PAA solid solution phase, and by the kinetics of crystallization reflected by the specific surface interactions. The interaction between PAA and A resulted in significant changes to the crystal bulk and surface free energy, particle size, and morphology. Accurate determination of the lattice constants revealed the formation of a secondary A-PAA phase with a deformed crystal lattice. The observed changes in the thermal behavior of the resulting solid solutions are explained mainly by changes of the entropy of the solid phase with smaller changes in enthalpy and even smaller elastic energy contributions.
著者Shekunov BY, Bristow S, Chow AHL, Cranswick L, Grant DJW, York P
期刊名稱Crystal Growth and Design
出版年份2003
月份7
日期1
卷號3
期次4
出版社AMER CHEMICAL SOC
頁次603 - 610
國際標準期刊號1528-7483
電子國際標準期刊號1528-7505
語言英式英語
Web of Science 學科類別Chemistry; Chemistry, Multidisciplinary; CHEMISTRY, MULTIDISCIPLINARY; Crystallography; CRYSTALLOGRAPHY; Materials Science; Materials Science, Multidisciplinary; MATERIALS SCIENCE, MULTIDISCIPLINARY

上次更新時間 2021-08-01 於 00:40