Tacrolimus in resistant primary membranous nephropathy - a report of 3 cases
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摘要Aim: To study the efficacy and safety of tacrolimus in primary membranous nephropathy. Method: We describe 3 patients with primary membranous nephropathy who were either resistant to or could not tolerate steroid with or without cytotoxic agents. They were treated with tacrolimus 0.2 mg/kg/day for 6 months. The dosage of tacrolimus was adjusted to keep a whole blood tacrolimus level of 5 - 10 ng/ml. Results: One patient had almost complete disappearance of proteinuria while the other 2 had at least 50% reduction in proteinuria. Proteinuria increased again in 2 of the patients after tacrolimus was stopped, but in neither of them proteinuria returned to the pretreatment level 6 months after tacrolimus was stopped. Conclusion: We conclude that tacrolimus may have a modest efficacy in the treatment of resistant membranous nephropathy.
著者Szeto CC, Leung CB, Lai FMM, Li PKT
期刊名稱Clinical Nephrology
詳細描述2003.
出版年份2003
月份4
日期1
卷號59
期次4
出版社DUSTRI-VERLAG DR KARL FEISTLE
頁次293 - 296
國際標準期刊號0301-0430
語言英式英語
關鍵詞membranous nephritis; nephrotic; tacrolimus
Web of Science 學科類別Urology & Nephrology; UROLOGY & NEPHROLOGY

上次更新時間 2021-27-01 於 23:58