Homocysteine, endothelial dysfunction, and coronary artery disease: Emerging strategy for secondary prevention
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AbstractAtherosclerosis is an important medical problem of the 21(st) century, but traditional risk factors could only account for 50% of the problem. Hyperhomocysteinemia is emerging as an independent atherosclerosis risk factor, associated with folate deficiency, renal failure, and relative deficiency of MTHFR (C677T polymorphism) or other enzymes depending on gender, age, and smoking status. Hyperhomocysteinemia has been reported to occur in 11-22% of western people, in 3-5% of normal asymptomatic Chinese subjects aged 18-70 years in Hong Kong, Macau, Sydney, and San Francisco, 23-36% of Chinese in Hong Kong with premature coronary artery disease, and 29% of a nonselective series of coronary subjects in Hong Kong. Evidence is accumulating that documents its associations with atherosclerosis disease in both case-control observations and prospective cohort studies, in vitro experiments, and in vivo experimental models in both animals and human subjects, as well as the successful improvement by homocysteine-lowering of endothelial function as surrogate atherosclerosis endpoints in asymptomatic human and coronary patients (secondary prevention). A number of large scale homocysteine-lowering trials are currently underway for stroke and heart attacks prevention. Collectively these trials will include more than 65,000 patients at high-risk for cardiovascular and stroke events, and should provide a reliable evidence-base for prevention.
All Author(s) ListWoo KS, Qiao M, Chook P, Poon PYK, Chan AKY, Lau JTF, Fung KP, Woo JLF
Name of Conference1st International Symposium on Cardiovascular Science
Start Date of Conference23/11/2001
End Date of Conference24/11/2001
Place of ConferenceHONG KONG
Journal nameJournal of Cardiac Surgery
Volume Number17
Issue Number5
Pages432 - 435
LanguagesEnglish-United Kingdom
Web of Science Subject CategoriesCardiac & Cardiovascular Systems; CARDIAC & CARDIOVASCULAR SYSTEMS; Cardiovascular System & Cardiology; Surgery; SURGERY

Last updated on 2021-18-09 at 00:51