Familial high myopia linkage to chromosome 18p
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摘要A locus for autosomal dominant high myopia was reported on chromosome 18p. We sought to confirm this finding and narrow the reported interval by analyzing high myopia among families of Hong Kong Chinese, in whom myopia is common. In 15 families with a possibly autosomal dominant inheritance of high myopia (greater than or equal to -6 dpt) in at least 2 generations, 10 chromosome 18p markers were analyzed for linkage with high myopia. Two-point linkage analysis showed trends toward linkage of markers D18S476 and D18S62 with high myopia, with maximum logarithm of odds (LOD) scores of at least 1.1 and 1.7, respectively. Multipoint analysis of those 2 markers gave a maximum LOD score of at least 2.1. To attempt to account for likely genetic heterogeneity, 5 families showing evidence of linkage of the 2 markers with high myopia were selected for further multipoint linkage analysis, resulting in a maximum LOD score of 2.4 at D18S476. While multiple genetic and environmental factors likely contribute to myopia, these data are consistent with the possibility of a locus on chromosome 18p.
著者Lam DSC, Tam POS, Fan DSP, Baum L, Leung YF, Pang CP
期刊名稱Ophthalmologica
出版年份2003
月份3
日期1
卷號217
期次2
出版社KARGER
頁次115 - 118
國際標準期刊號0030-3755
電子國際標準期刊號1423-0267
語言英式英語
關鍵詞chromosome 18; myopia gene; myopia, high
Web of Science 學科類別Ophthalmology; OPHTHALMOLOGY

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