A mechanosensitive cation channel in endothelial cells
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AbstractA mechanosensitive Ca2+-permeable channel is present in vascular endothelial cells. The activity of this channel increases in response to hemodynamic blood flow. Recently, it has been found that the activity of this channel may be regulated by cGMP through a protein kinase G-dependent pathway. Inhibition of the channel by cGMP abolishes the Ca2+ influx elicited by flow. Several inhibitors of the cation channel including Gd3+, Ni2+, and SK&F-96365 also inhibit the Ca2+ influx due to flow stimulation. These data suggest that a mechanosensitive cation channel is the primary pathway mediating the flow-induced Ca2+ entry in vascular endothelial cells.
All Author(s) ListYao XQ, Kwan HY, Huang Y
Name of Conference1st international Symposium of Cardiovascular Science-From Bench to Bedside
Start Date of Conference23/11/2001
End Date of Conference24/11/2001
Place of ConferenceHONG KONG
Journal nameJournal of Cardiac Surgery
Year2002
Month7
Day1
Volume Number17
Issue Number4
PublisherBLACKWELL PUBLISHING INC
Pages340 - 341
ISSN0886-0440
LanguagesEnglish-United Kingdom
Web of Science Subject CategoriesCardiac & Cardiovascular Systems; CARDIAC & CARDIOVASCULAR SYSTEMS; Cardiovascular System & Cardiology; Surgery; SURGERY

Last updated on 2020-20-09 at 03:26