Actions of prostanoids to induce emesis and defecation in the ferret
Publication in refereed journal


Times Cited
Web of Science22WOS source URL (as at 25/09/2020) Click here for the latest count
Altmetrics Information
.

Other information
AbstractSeveral prostanoids were investigated for their ability to induce emesis and/or defecation and tenesmus in the ferret. The rank order of emetic potency (dose producing four episodes. D-4) was: sulprostone (5 mug/kg)> 11alpha,9alpha-epoxymethano-15S-hydroxyprosta-5Z,13E-dienoic acid (U46619; 8 mug/kg)>misoprostol (27 mug/kg)> 17-phenyl-omega-trinor prostaglandin E-2 (53 mug/kg)>prostaglandin E-2 (94 mug/kg)>5-(6-carboxyhexyl) -1-(3-cyclohexyl-3-hydroxypropyl) hydantoin (BW245C: 148 mug/kg) >> prostaglandin F-2alpha (13,500 mug/kg). Emesis was also induced by iloprost (D-4 not determined) and prostaglandin E-2 methyl ester (D-4 = 350 mug/kg). Cicaprost and fluprostenol were virtually inactive they also failed to modify copper sulphate ( 100 mg/kg, intragastric)-induced emesis ( P>0.05), although cicaprost potentiated apomorphine (0.25 mg/kg, s.c.)-induced emesis (P<0.05). U46619-induced emesis was antagonised by vapiprost (P<0.05). The rank order of potency to produce defecation and tenesmus (dose producing three episodes) was: sulprostone (12 mug/kg)>misoprostol (15 mug/kg)>17-phenyl-omega-trinor prostaglandin E-2 (94 mug/kg)>prostaglandin E-2 (113 mug/kg)>fluprostenol (158 mug/kg) >>prostaglandin F-2alpha (1759 mug/kg); prostaglandin E-2 methyl ester also induced defecation (196 mug/kg). Data are discussed in relation to mechanisms involved in emesis and defecation. (C) 2002 Elsevier Science B.V All rights reserved.
All Author(s) ListKan KKW, Jones RL, Ngan MP, Rudd JA
Journal nameEuropean Journal of Pharmacology
Year2002
Month10
Day25
Volume Number453
Issue Number2-3
PublisherELSEVIER SCIENCE BV
Pages299 - 308
ISSN0014-2999
eISSN1879-0712
LanguagesEnglish-United Kingdom
Keywords(ferret); defecation; emesis; prostanoid
Web of Science Subject CategoriesPharmacology & Pharmacy; PHARMACOLOGY & PHARMACY

Last updated on 2020-25-09 at 14:26