The contribution of metformin to glycaemic control in patients with Type 2 diabetes mellitus receiving combination therapy with insulin
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AbstractCombination therapy of oral hypoglycaemic agents and insulin is a therapeutic option for those who have deterioration in glycaemic control. We examined the contribution of metformin by withdrawing it from Type 2 diabetic patients who had been stabilised on combination therapy. Fifty-one subjects with Type 2 diabetes and secondary oral hypoglycaemic agent failure were studied in a randomised, open and parallel study. In the first phase of 36 weeks, subjects were stabilised on combined therapy of sulphonylureas and nocturnal insulin, with or without metformin. During the second phase, metformin was withdrawn. The primary variables for efficacy were HbA(1c), fasting plasma glucose and 3-point capillary blood glucose profiles. After stabilisation with combination therapy, those subjects on metformin used less insulin to maintain glycaemic control (13.7 +/- 6.8 vs. 23.0 +/- 9.4 U/day, P = 0.001) and had lower HbA(1c) values (8.13 +/- 0.89 vs. 9.05 +/- 1.30%, P = 0.003) compared with those not given metformin. Withdrawal of metformin therapy caused deterioration in HbA(1c) (P = 0.001). This study confirms that metformin plays an important role in the success of the combination therapy. The rational use of metformin and sulphonylurea together with insulin will help to improve metabolic control in Type 2 diabetes patients who have secondary drug failure. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
All Author(s) ListTong PC, Chow CC, Jorgensen LN, Cockram CS
Journal nameDiabetes Research and Clinical Practice
Volume Number57
Issue Number2
Pages93 - 98
LanguagesEnglish-United Kingdom
Keywordscombination therapy; insulin; metformin; Type 2 diabetes
Web of Science Subject CategoriesEndocrinology & Metabolism; ENDOCRINOLOGY & METABOLISM

Last updated on 2020-18-11 at 00:30