Independent effect of vitamin B-12 deficiency on hematological status in older Chinese vegetarian women
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AbstractWe have examined the independent effect of vitamin B-12 deficiency on hemtological indices in older Chinese vegetarian women using a cross-sectional study design: 119 women older than 55 years who had been vegetarian for more than 3 years were studied. Fasting blood samples were taken for complete blood count, serum Iron, total serum Iron binding capacity, serum iron saturation, serum vitamin B-12, serum folate, serum methylmalonic acid levels (MMA), and renal function test. Subjects with Iron deficiency (iron saturation <15%) and those with serum creatinine >150 mmol/L were excluded. The prevalence of definite vitamin B-12 deficiency (vitamin B-12 level <150 pmol/L and MMA greater than or equal to 0.4 mumol/L) was 42%. Another 2.8% had possible vitamin B12 deficiency (either criterion). The prevalence of iron deficiency was 10%. After exclusions, 96 subjects were further analyzed. Vitamin B-12 deficiency defined by serum vitamin B12 and MMA was associated with a decrease in hemoglobin concentrations by up to 0.9 g/dL, but it was not associated with an increase in mean corpuscular volume (MCV). Serum MMA but not vitamin B-12 levels correlated inversely with hemoglobin and platelet counts and positively with MCV, after adjustment of confounding factors. However, the percentage of subjects with anemia did not increase significantly until serum MMA became >1.0 pmol/L. In conclusion, vitamin B-12 deficiency was associated with a significant decrease in hemoglobin concentration. However, anemia associated with vitamin B-12 deficiency was seldom macrocytic. We recommend that older vegetarians should be given vitamin B-12 supplements routinely. Am. J. Hematol. 70:186-190, 2002. (C) 2002 Wiley-Liss, Inc.
All Author(s) ListKwok T, Cheng G, Woo J, Lai WK, Pang CP
Journal nameAmerican Journal of Hematology
Volume Number70
Issue Number3
Pages186 - 190
LanguagesEnglish-United Kingdom
Keywordsaged; anemia; vegetarianism; vitamin B-12
Web of Science Subject CategoriesHematology; HEMATOLOGY

Last updated on 2020-03-12 at 00:39