The central roles of obesity-associated dyslipidaemia, endothelial activation and cytokines in the Metabolic Syndrome - an analysis by structural equation modelling
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AbstractHYPOTHESIS: The multi-faceted components of the metabolic syndrome now include markers of inflammation and endothelial activation. Despite this growing body of epidemiological data, standard statistical methods fail to evaluate the nature of these associations adequately. In this pilot study, we hypothesize that obesity may lead to endothelial activation which is in part mediated by dyslipidaemia and proinflammatory cytokines. These factors interact to give rise to hyperinsulinaemia, hypertension and an anti-fibrinolytic state. To test this hypothesis, we used confirmatory factor analysis and structural equation modelling to fit these data to a model designed on theoretical grounds.
All Author(s) ListChan JCN, Cheung JCK, Stehouwer CDA, Emeis JJ, Tong PCY, Ko GTC, Yudkin JS
Journal nameInternational Journal of Obesity
Volume Number26
Issue Number7
Pages994 - 1008
LanguagesEnglish-United Kingdom
Keywordsanti-fibrinolysis; dyslipidaemia; endothelial activation; factor analysis; interleukin-6 (IL6); metabolic syndrome; obesity; structural equation modelling; tumor necrosis factor-alpha (TNF alpha) hyperinsulinaemia
Web of Science Subject CategoriesEndocrinology & Metabolism; ENDOCRINOLOGY & METABOLISM; Nutrition & Dietetics; NUTRITION & DIETETICS

Last updated on 2020-02-12 at 00:32