Acute toxicity of adjuvant doxorubicin and cyclophosphamide for early breast cancer - a retrospective review with an historic of Chinese patients and comparison Western series
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AbstractA cohort of 85 Chinese breast cancer patients who received adjuvant chemotherapy with doxorubicin and cyclophosphamide was found to have a significantly higher incidence of grade 3 (n=44, 52%) and grade 4 (n=21, 25%) neutropenia when compared with an historic Western cohort. Also noted was a higher incidence of hepatotoxicity (n=8, 9%). When compared to Caucasian patients, the higher myelotoxicity in our patients may be related to ethnic variation in susceptibility to chemotherapy-related toxicity, lower body mass index with higher percentage of body fat composition, and the popular practice of concurrent alternative medicine during chemotherapy. The hi-her incidence of hepatoxicity was possibly associated with endemic chronic hepatitis B infection in this geographical area. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
All Author(s) ListMa B, Yeo W, Hui P, Ho WM, Johnson PJ
Journal nameRadiotherapy and Oncology
Volume Number62
Issue Number2
Pages185 - 189
LanguagesEnglish-United Kingdom
Keywordsacute toxicity; adjuvant chemotherapy; breast cancer; Chinese; cyclophosphamide; doxorubicin
Web of Science Subject CategoriesOncology; ONCOLOGY; Radiology, Nuclear Medicine & Medical Imaging; RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Last updated on 2021-14-10 at 00:32