Synthesis of antisense oligonucleotide-peptide conjugate targeting to GLUT-1 in HepG-2 and MCF-7 cells
Publication in refereed journal


Times Cited
Web of Science25WOS source URL (as at 02/12/2020) Click here for the latest count
Altmetrics Information
.

Other information
AbstractA simple procedure for the preparation of oligonucleotide-peptide conjugate was developed. p-Hydroxybenzoic acid was used as a linker for the connection of the fragments of peptide and oligonucleotide. It was found that such formed linkage was stable under the conditions of conjugate synthesis. The designed conjugate targeting to GLUT-1 showed up to 50% inhibition of cell proliferation in HepG-2 and MCF-7 cells. Comparing to the results from the expressed antisense RNA in cancer cells, it was proposed that the conjugate of signal peptide mimic and antisense oligonucleotide could improve the permeability of antisense oligonucleotide through cell membrane.
All Author(s) ListChen CP, Li XX, Zhang LR, Min JM, Chan JYW, Fung KP, Wang SQ, Zhang LH
Journal nameBioconjugate Chemistry
Year2002
Month5
Day1
Volume Number13
Issue Number3
PublisherAMER CHEMICAL SOC
Pages525 - 529
ISSN1043-1802
LanguagesEnglish-United Kingdom
Web of Science Subject CategoriesBiochemical Research Methods; BIOCHEMICAL RESEARCH METHODS; Biochemistry & Molecular Biology; BIOCHEMISTRY & MOLECULAR BIOLOGY; Chemistry; Chemistry, Multidisciplinary; CHEMISTRY, MULTIDISCIPLINARY; Chemistry, Organic; CHEMISTRY, ORGANIC

Last updated on 2020-03-12 at 00:38