Left ventricular long-axis changes in early diastole and systole: impact of systolic function on diastole
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AbstractImpaired long-axis motion is a sensitive marker of systolic myocardial dysfunction, but no data are available that relate long-axis changes in systole with those in diastole, particularly in subjects with diastolic dysfunction and a 'normal' left ventricular (LV) ejection fraction. A total of 311 subjects (including 105 normal healthy volunteers) aged 20-89 years with variable degrees of systolic function (LV ejection fraction range 0.15-0.84) and diastolic function were studied using tissue Doppler echocardiography and M-mode echocardiography to determine mean mitral annular amplitude and peak velocity in systole and early and late diastole. The LV systolic mitral annular amplitude (S-LAX, where LAX is long-axis amplitude) and peak velocity (S-m) correlated well with the respective early diastolic components (E-LAX and E-m) and late diastolic (atrial) components (A(LAX) and A(m)). A non-linear equation fitted better than a linear relationship (non-linear model: S-LAX against E-LAX, r(2) = 0.67; S-m against E-m, r(2) = 0,60; S-LAX against A(LAX) and S-m against A(m), r(2) = 0.42), After adjusting for age, sex and heart rate, linear relationships of early diastolic (E-LAX, r(2) = 0.70; E-m, r(2) = 0.60) and late diastolic (A(LAX), r(2) = 0.61; A(m), r(2) = 0.64) long-axis amplitudes and velocities with the respective values for S-LAX and S-m were found, even in those subjects with apparently 'isolated' diastolic dysfunction. Long-axis changes in systole or diastole did not correlate with Doppler mitral velocities. We conclude that ventricular long-axis changes in early diastole are closely related to systolic function, even in subjects with diastolic dysfunction. 'Pure' or isolated diastolic dysfunction is uncommon.
All Author(s) ListYip GW, Zhang Y, Tan PY, Wang M, Ho PY, Brodin LA, Sanderson JE
Journal nameClinical Science
Volume Number102
Issue Number5
Pages515 - 522
LanguagesEnglish-United Kingdom
Keywordsearly diastole; echocardiography; long-axis function; systolic function
Web of Science Subject CategoriesMedicine, Research & Experimental; MEDICINE, RESEARCH & EXPERIMENTAL; Research & Experimental Medicine

Last updated on 2021-18-09 at 00:49