Ropivacaine undergoes slower systemic absorption from the caudal epidural space in children than bupivacaine
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摘要We compared the systemic absorption of ropivacaine and bupivacaine after caudal epidural administration in children. Twenty ASA physical status I or II children aged 1-7 yr undergoing elective hypospadias repair were randomized after the induction of general anesthesia to receive a single caudal epidural injection of 2 mg/kg of either ropivacaine 0.2% (R) or bupivacaine 0.2% (B) in a double-blinded fashion. Peripheral venous blood samples (1 mL) were obtained before and 1, 5, 10, 15, 20, 30, 40, 50, 60, 70, 80, 90, and 120 min after the caudal injection. The total R and B concentration was measured in plasma by using high-performance liquid chromatography. All blocks were successful, and there were no complications. The peak plasma concentration (mean +/- SD) (R = 0.67 +/- 0.16 and B = 0.73 +/- 0.23 mug/mL) and the area under the plasma concentration curve (R = 61.9 +/- 20.6 and B = 62.7 +/- 18.2 mug . mL(-1) . min(-1)) were comparable between the two study groups. The median (range) time to attain peak plasma concentration was significantly slower in children who received ropivacaine (R = 65 [10-120] min and B = 20 [15-50] min, P < 0.05). We conclude that ropivacaine undergoes slower systemic absorption from the caudal epidural space in children than does bupivacaine.
著者Karmakar MK, Aun CST, Wong ELY, Wong ASY, Chan SKC, Yeung CK
會議名稱19th Annual Meeting of the European-Society-of-Regional-Anesthesia (ESRA)
會議開始日01.09.2000
會議地點ROME
期刊名稱Anesthesia and Analgesia
出版年份2002
月份2
日期1
卷號94
期次2
出版社LIPPINCOTT WILLIAMS & WILKINS
頁次259 - 265
國際標準期刊號0003-2999
電子國際標準期刊號1526-7598
語言英式英語
Web of Science 學科類別Anesthesiology; ANESTHESIOLOGY

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