Preclinical ex vivo expansion of cord blood hematopoietic stem and progenitor cells: duration of culture; the media, serum supplements, and growth factors used; and engraftment in NOD/SCID mice
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AbstractBACKGROUND: Ex vivo expansion of cord blood (CB) hematopoietic stem and progenitor cells increases cell dose and may reduce the severity and duration of neutropenia and thrombocytopenia after transplantation. This study's purpose was to establish a clinically applicable culture system by investigating the use of cytokines, serum-free media, and autologous plasma for the expansion of CB cells and the engraftment of expanded product in nonobese diabetic/severe combined immunodeficient (NOD/SCID) mice.
All Author(s) ListLam AC, Li K, Zhang XB, Li CK, Fok TF, Chang AMZ, James AE, Tsang KS, Yuen PMP
Journal nameTransfusion
Year2001
Month12
Day1
Volume Number41
Issue Number12
PublisherAMER ASSOC BLOOD BANKS
Pages1567 - 1576
ISSN0041-1132
eISSN1537-2995
LanguagesEnglish-United Kingdom
Web of Science Subject CategoriesHematology; HEMATOLOGY

Last updated on 2020-16-10 at 02:17