Circulating cell-free Epstein-Barr virus DNA levels in patients with EBV-associated lymphoid malignancies
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AbstractEpstein-Barr virus (EBV) is a human lymphotrophic herpesvirus implicated in the development of several lymphoid malignancies. Recently, detection of cell-free EBV DNA in sera or plasma from patients with EBV-associated malignancies has been reported. However, most published studies are qualitative in nature, with only a few providing quantitative data. We have described the temporal changes of plasma EBV DNA levels in patients with EBV-associated lymphoid malignancies during therapy using quantitative real-time PCR. A close correlation between plasma EBV DNA levels and therapeutic response was observed. Our aim was to update our results and to assess the role of the plasma EBV DNA levels as a molecular marker for disease monitoring in patients with EBV-associated lymphoid malignancies.
All Author(s) ListLei KIK, Chan LYS, Chan WY, Johnson PJ, Lo YMD
Name of Conference2nd International Symposium on Circulating Nucleic Acids in Plasma or Serum held in conjunction with the 6th Annual Scientific Symposium of the Hong-Kong-Cancer-Institute
Start Date of Conference20/02/2001
End Date of Conference21/02/2001
Place of ConferenceHONG KONG
Journal nameAnnals of the New York Academy of Sciences
Detailed descriptioned. by LO Y.M. Dennis; CHIU W.K. Rossa; JOHN SON J.Philip. vol.945
Volume Number945
Pages80 - 83
LanguagesEnglish-United Kingdom
KeywordsDNA; Epstein-Barr virus; lymphoid malignancies; plasma
Web of Science Subject CategoriesBiochemistry & Molecular Biology; Multidisciplinary Sciences; Science & Technology - Other Topics

Last updated on 2021-23-09 at 00:00