Epigenetic tumor markers in plasma and serum - Biology and applications to molecular diagnosis and disease monitoring
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AbstractCirculating tumor DNA in plasma and serum has been demonstrated to reflect the biological characteristics of tumors, including the rates of apoptosis and necrosis. Aberrant promoter methylation has increasingly emerged as a fundamental molecular abnormality associated with loss of critical gene functions during carcinogenesis. This epigenetic inheritance has significant biological implications for early tumor initiation and cancer progression or metastasis formation. The promoter-region methylation is crucial in transcriptional silencing of tumor suppressor genes, DNA repair genes, and metastasis inhibitor genes, and is linked to the predisposition of genetic alterations of other cancer-associated genes. Of clinical relevance, epigenetic markers in plasma and serum have recently been established as specific and sensitive biomarkers for early and noninvasive screening, risk assessment, and monitoring of neoplastic diseases. A panel of epigenetic markers may possibly allow the detection of circulating tumor DNA in virtually all patients with different cancer types. Furthermore, the prognostic value of aberrant DNA methylation and therapeutic implications of demethylation of methylated genes could further improve the management of patients with different kinds of cancer.
All Author(s) ListWong IHN, Lo YMD, Johnson PJ
Name of Conference2nd International Symposium on Circulating Nucleic Acids in Plasma or Serum held in conjunction with the 6th Annual Scientific Symposium of the Hong-Kong-Cancer-Institute
Start Date of Conference20/02/2001
End Date of Conference21/02/2001
Place of ConferenceHONG KONG
Journal nameAnnals of the New York Academy of Sciences
Detailed descriptionvol.945
Volume Number945
Pages36 - 50
LanguagesEnglish-United Kingdom
KeywordsDNA hypermethylation; metastasis; methylation-specific polymerase chain reaction (MSP); plasma/serum; real-time quantitative MSP; transcriptional repression; tumor recurrence
Web of Science Subject CategoriesBiochemistry & Molecular Biology; Multidisciplinary Sciences; Science & Technology - Other Topics

Last updated on 2021-14-09 at 00:36