A framework for the molecular classification of circulating tumor markers
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AbstractNew molecular biological technologies, especially polymerase chain reaction (PCR) and mass spectroscopy, have expanded the pool of molecular targets for cancer diagnosis, monitoring, and prognosis using plasma or serum as the substrate. In this review, a framework is described following the "life history" of a protein-starting with DNA [endogenous (nuclear or mitochondrial) or exogenous (viral)], followed by RNA [endogenous (cell-based or cell-free) or exogenous (viral)], and culminating in protein (either the native protein or the glycan portion of glycoproteins). Each of these levels provides unique opportunities to achieve specificity for cancer diagnosis.
All Author(s) ListJohnson PJ
Name of Conference2nd International Symposium on Circulating Nucleic Acids in Plasma or Serum held in conjunction with the 6th Annual Scientific Symposium of the Hong-Kong-Cancer-Institute
Start Date of Conference20/02/2001
End Date of Conference21/02/2001
Place of ConferenceHONG KONG
Journal nameAnnals of the New York Academy of Sciences
Detailed descriptionvol.945
Volume Number945
Pages8 - 21
LanguagesEnglish-United Kingdom
Keywordscancer; molecular markers; plasma nucleic acids
Web of Science Subject CategoriesBiochemistry & Molecular Biology; Multidisciplinary Sciences; Science & Technology - Other Topics

Last updated on 2020-31-07 at 02:44