Circulating nucleic acids in plasma and serum: An overview
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AbstractThe recent interest in nucleic acids in plasma and serum has opened up numerous new areas of investigation and new possibilities for molecular diagnosis. In oncology, tumor-derived genetic changes, epigenetic alterations, and viral nucleic acids have been found in the plasma/serum of cancer patients. These findings have important implications for the detection, monitoring, and prognostication of many types of malignancies. In prenatal diagnosis, the discovery of fetal DNA in maternal plasma and serum has provided a noninvasive source of fetal genetic material for analysis. This development has important implications for the realization of noninvasive prenatal diagnosis and has provided new methods for the monitoring of pregnancy-associated disorders. Plasma DNA technology has also found recent applications in the fields of organ transplantation, posttrauma monitoring, and infectious agent detection. Future areas of study include circulating RNA in plasma and the elucidation of the biology of release, clearance, and possible functionality of plasma nucleic acids.
All Author(s) ListLo YMD
Name of Conference2nd International Symposium on Circulating Nucleic Acids in Plasma or Serum held in conjunction with the 6th Annual Scientific Symposium of the Hong-Kong-Cancer-Institute
Start Date of Conference20/02/2001
End Date of Conference21/02/2001
Place of ConferenceHONG KONG
Journal nameAnnals of the New York Academy of Sciences
Volume Number945
LanguagesEnglish-United Kingdom
Keywordscancer detection; circulating RNA; noninvasive prenatal diagnosis; organ transplantation; overview; plasma DNA
Web of Science Subject CategoriesBiochemistry & Molecular Biology; Multidisciplinary Sciences; Science & Technology - Other Topics

Last updated on 2020-08-08 at 02:22