Chromosome 11 copy number gains and Epstein-Barr virus-associated malignancies
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AbstractEpstein-Barr virus (EBV) genome can be found in many malignant tumors in China. Previous data of interphase cytogenetics, by comparative genomic hybridization and/or fluorescence in situ hybridization, on nasopharyngeal carcinomas and natural killer cell-type non-Hodgkin lymphomas in Hong Kong have noted gains in chromosome 11. This study compares the frequency of chromosome 11 copy number gains in three different types of EBV-associated tumors in Hong Kong. Using alpha-satellite probes, the authors studied by fluorescence in situ hybridization 31 EBV-positive tumors comprising 10 EBV-positive gastric carcinomas, 8 lung lymphoepitheliomalike carcinomas, and 13 non-Hodgkin lymphomas. Trisomy or polysomy 11 was detected in 10 of 10 (100%) EBV-positive gastric carcinomas, 6 of 8 (75%) lung lymphoepithelioma- like carcinomas, and 4 of 13 (30.8%) non-Hodgkin lymphomas. Compared with the EBV-positive gastric carcinomas, the 10 EBV-negative gastric carcinomas that were also studied showed chromosome 11 copy number gains in 3 of 10 (30%), a significantly lower frequency. The authors conclude that gains in chromosome 11 are common in EBV-associated malignancies in Hong Kong, with the strongest association found in gastric carcinoma. There seems to be differences between EBV-associated tumors of different locations, and between gastric carcinomas with and without EBV.
All Author(s) ListChan WY, Chan ABW, Liu AGY, Chow JHS, Ng EKW, Chung SSC
Name of Conference9th Biennial Conference of the International-Association-for-Research-on-Epstein-Barr-Virus-and-Associated-Diseases
Start Date of Conference22/06/2000
End Date of Conference27/06/2000
Journal nameDiagnostic Molecular Pathology
Year2001
Month12
Day1
Volume Number10
Issue Number4
PublisherLIPPINCOTT WILLIAMS & WILKINS
Pages223 - 227
ISSN1052-9551
LanguagesEnglish-United Kingdom
Keywordschromosome 11; comparative genomic hybridization; Epstein-Barr virus; fluorescence in situ hybridization; gastric; lung; natural killer
Web of Science Subject CategoriesBiochemistry & Molecular Biology; BIOCHEMISTRY & MOLECULAR BIOLOGY; Biotechnology & Applied Microbiology; BIOTECHNOLOGY & APPLIED MICROBIOLOGY; Pathology; PATHOLOGY

Last updated on 2020-02-07 at 05:29