Kaposiform hemangioendothelioma: Five patients with cutaneous lesion and long follow-up
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摘要Kaposiform hemangioendothelioma is a rare locally aggressive vascular tumor of the skin, deep soft tissue, and bone in children, characterized by infiltrating nodules and sheets of spindle cells, and unmistakable resemblance to Kaposi's sarcoma. More than 60 patients with such tumor have been reported so far, and while many have died as a result of extensive disease and severe coagulopathy, the long-term biologic behavior of this tumor remains undetermined. We describe five patients with kaposiform hemangioendothelioma and a mean follow-up of 19 years, ranging from 8 to 35 years. This report emphasizes on the importance of cutaneous lesions being the most commonly affected site, but also for its clinical diversity. Early diagnosis is possible even for a small skin lesion, which may be critical for the treatment of a potentially fatal deep-seated extensive tumor. All five patients are well, and three of them with persistent vascular tumor, which has carried two patients from childhood to adult. Although the behavior of this tumor might have been modified by radiation or interferon in three patients, this series indicates that kaposiform hemangioendothelioma is incapable of metastasis, despite a protracted course of many decades with no tendency for spontaneous regression.
著者Lai FMM, To KF, Choi PCL, Leung PC, Kumta SM, Yuen PPM, Lam WY, Cheung ANY, Allen PW
期刊名稱Modern Pathology
出版年份2001
月份11
日期1
卷號14
期次11
出版社LIPPINCOTT WILLIAMS & WILKINS
頁次1087 - 1092
國際標準期刊號0893-3952
電子國際標準期刊號1530-0285
語言英式英語
關鍵詞angiosarcoma; hemangioma; interferon; kaposi's sarcoma; kaposiform hemangioendothelioma; Kasabach-Merritt syndrome; Tufted angioma
Web of Science 學科類別Pathology; PATHOLOGY

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