In vitro evaluation of secoiridoid glucosides from the fruits of Ligustrum lucidum as antiviral agents
Publication in refereed journal

香港中文大學研究人員

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摘要Six secoiridoid glucosides, lucidumoside C (1), oleoside dimethylester (2), neonuezhenide (3), oleuropein (4), ligustroside (5) and lucidumoside A (6), isolated from the fruits of Ligustrum lucidum (Oleaceae), were examined in vitro for their activities against four strains of pathogenic viruses, namely herpes simplex type 1 virus (HSV-1), influenza type A virus (Flu A), respiratory syncytial virus (RSV) and parainfluenza type 3 virus (Para 3). Antiviral activities were evaluated by the cytopathic effect (CPE) inhibitory assay. The purpose was to check if the antioxidative potency of these glucosides correlated with their antiviral potency. Results showed that none of the glucosides had any significant activity against HSV-1 and Flu A. Oleuropein, however, showed significant antiviral activities against RSV and Para 3 with IC50 value of 23.4 and 11.7 mug/ml, respectively. Lucidumoside C, oleoside dimethylester and ligustroside showed potent or moderate antiviral activities against Para 3 with IC50 values of 15.6-20.8 mug/ml. These results also documented that the anti-oxidative potency of these secoiriodoid glucosides was not directly related to their antiviral effects.
著者Ma SC, He ZD, Deng XL, But PPH, Ooi VEC, Xu HX, Lee SHS, Lee SF
期刊名稱Chemical and Pharmaceutical Bulletin
出版年份2001
月份11
日期1
卷號49
期次11
出版社PHARMACEUTICAL SOC JAPAN
頁次1471 - 1473
國際標準期刊號0009-2363
語言英式英語
關鍵詞antiviral activity; lucidumoside C; oleuropein; secoiridoid glucoside
Web of Science 學科類別Chemistry; Chemistry, Medicinal; CHEMISTRY, MEDICINAL; Chemistry, Multidisciplinary; CHEMISTRY, MULTIDISCIPLINARY; Pharmacology & Pharmacy; PHARMACOLOGY & PHARMACY

上次更新時間 2021-27-02 於 01:22