Clinical significance of P-glycoprotein immunohistochemistry and doxorubicin binding assay in patients with osteosarcoma
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摘要In 45 osteosarcoma patients. mean age 18 (4-61) years and followed for 14 (5-48) months, we studied the sensitivity to doxorubicin as well as P-glycoprotein expression, and compared these with the extent of tumour necrosis following chemotherapy. Doxorubicin assay was positive in 37 patients in whom necrosis induced by chemotherapy was good in 20 and poor in 17. Metastases developed in nine patients. In eight patients in whom doxorubicin assay indicated tumour resistance, chemonecrosis was poor and all developed pulmonary metastases. P-glycoprotein was studied in pre-treatment biopsies and post-treatment resection specimens. Its expression was positive in 16 patients in whom the necrosis induced by chemotherapy was good in four and poor in 12. In 29 patients with negative P-glycoprotein expression. necrosis was good in 16 and poor in 13. The doxorubicin sensitivity had a high correlation with chemonecrosis (P = 0.006) and the incidence of metastases (P < 0.001). However, P-glycoprotein expression at the time of diagnosis did not correlate statistically with chemonecrosis (P = 0.066). Doxorubicin sensitivity prior to treatment is a better determinant of the response to chemotherapy and clinical outcome than is the P-glycoprotein expression.
著者Kumta SM, Zhu QS, Lee KM, Griffith J, Chow LT, Leung PC
期刊名稱International Orthopaedics
出版年份2001
月份10
日期1
卷號25
期次5
出版社SPRINGER-VERLAG
頁次279 - 282
國際標準期刊號0341-2695
電子國際標準期刊號1432-5195
語言英式英語
Web of Science 學科類別Orthopedics; ORTHOPEDICS

上次更新時間 2020-29-11 於 02:11