Measurement of the layered compressive properties of trypsin-treated articular cartilage: an ultrasound investigation
Publication in refereed journal

香港中文大學研究人員

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替代計量分析
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摘要An ultrasound-compression system has been developed for the study of the layered biomechanical properties of articular cartilage. Cartilage specimens harvested from the bovine patella groove, with and without trypsin digestion, were tested using this system. It was noted that a large ultrasound reflection can be detected in the interface of the trypsin digestion front, This ultrasound reflection signal was used to differentiate the deformations of different portions of the cartilage throughout its depth when a load was applied. The equilibrium compression moduli of the digested, undigested and entire portions of articular cartilage were measured. The modulus of the cartilage without any digestion was 660 +/- 230 kPa. After 1h digestion with 1 mg ml(-1) tryosin solution, the thickness of the digested portion was 0.50 +/-0.06 mm, and the modulus of the entire cartilage layer changed to 125 +/- 42 kPa. The moduli of the digested and undigested portions were 58 +/- 24 kPa and 470 +/- 31 kPa, respectively. Similar results were obtained for the cartilage with trypsin digestion for 2h.
著者Zheng YP, Ding CX, Bai J, Mak AFT, Qin L
期刊名稱Medical and Biological Engineering and Computing
出版年份2001
月份9
日期1
卷號39
期次5
出版社PETER PEREGRINUS LTD
頁次534 - 541
國際標準期刊號0140-0118
電子國際標準期刊號1741-0444
語言英式英語
關鍵詞articular cartilage; biomechanics; elastography; osteoarthritis; ultrasound technique
Web of Science 學科類別Computer Science; Computer Science, Interdisciplinary Applications; COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS; Engineering; Engineering, Biomedical; ENGINEERING, BIOMEDICAL; Mathematical & Computational Biology; MATHEMATICAL & COMPUTATIONAL BIOLOGY; Medical Informatics; MEDICAL INFORMATICS

上次更新時間 2021-04-12 於 23:34