cGMP-regulated store-operated calcium entry in human hepatoma cells
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AbstractThis study aimed to investigate cGMP-regulated store-operated Ca2+ entry in human 7721 hepatoma cells. [Ca2+](i) was measured using Fura2/AM. After incubation of the cells with 4 mum thapsigargin, Ca2+ entry was evoked by application of 1 mm Ca2+ to extracellular solution and was blocked by 3 mm Ni2+, indicating the presence of store-operated Ca2+ entry in human 7721 hepatoma cell line. Application of 8-Br-cGMP reduced the [Ca2+](i) in hepatoma 7721 cells by 80%. These data demonstrated for the first time that store-operated Ca2+ entry pathway is present in human hepatoma cells, which is regulated by cGMP. (C) 2001 Academic Press.
All Author(s) ListJiang JL, Yu MK, Chen ZN, Chan HC
Journal nameCell Biology International
Volume Number25
Issue Number10
Pages993 - 995
LanguagesEnglish-United Kingdom
KeywordscGMP; hepatoma cell; store-operated Ca2+ entry
Web of Science Subject CategoriesCell Biology; CELL BIOLOGY

Last updated on 2021-22-09 at 23:56