Distinction between relaxations induced via prostanoid EP4 and IP1 receptors in pig and rabbit blood vessels
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Abstract1 Our study shows that the prostacyclin analogues AFP-07 and cicaprost are moderately potent agonists for prostanoid EP4 receptors, in addition to being highly potent IP1 receptor agonists. Both activities were demonstrated on piglet and rabbit saphenous veins, which are established EP4 preparations.
All Author(s) ListJones RL, Chan KM
Journal nameBritish Journal of Pharmacology
Year2001
Month9
Day1
Volume Number134
Issue Number2
PublisherNATURE PUBLISHING GROUP
Pages313 - 324
ISSN0007-1188
eISSN1476-5381
LanguagesEnglish-United Kingdom
KeywordsAH 23848; cicaprost; iloprost; prostacyclin; prostaglandin E-2; prostanoid EP receptors; prostanoid IP receptors; sulprostone; vascular smooth muscle
Web of Science Subject CategoriesPharmacology & Pharmacy; PHARMACOLOGY & PHARMACY

Last updated on 2020-20-10 at 02:28