Eicosapentaenoic acid modulates cyclin expression and arrests cell cycle progression in human leukemic K-562 cells
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香港中文大學研究人員

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摘要Eicosapentaenoic acid (EPA) is a polyunsaturated fatty acid (20:5 omega3) found primarily in aquatic organisms. We have shown previously that EPA inhibits the growth but is not toxic to human leukemic K-562 cells. In this study, the antiproliferative effect of EPA on the leukemic cells was further determined and its impacts on cell cycle progression and cyclin expression were investigated. EPA inhibited proliferation of K-562 cells, which was associated with accumulation of G0/G1 cells and down-regulation of cyclin E expression. Cyclin B1-expressing cells were also reduced showing that down-regulation of cyclin expression might be important in the anti-proliferation of EPA.
著者Chiu LCM, Ooi VEC, Wan JMF
期刊名稱International Journal of Oncology
出版年份2001
月份10
日期1
卷號19
期次4
出版社SPANDIDOS PUBL LTD
頁次845 - 849
國際標準期刊號1019-6439
電子國際標準期刊號1791-2423
語言英式英語
關鍵詞anti-proliferation; cyclin B1; cyclin E; eicosapentaenoic acid; flow cytometry
Web of Science 學科類別Oncology; ONCOLOGY

上次更新時間 2021-13-01 於 23:43