Eicosapentaenoic acid modulates cyclin expression and arrests cell cycle progression in human leukemic K-562 cells
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AbstractEicosapentaenoic acid (EPA) is a polyunsaturated fatty acid (20:5 omega3) found primarily in aquatic organisms. We have shown previously that EPA inhibits the growth but is not toxic to human leukemic K-562 cells. In this study, the antiproliferative effect of EPA on the leukemic cells was further determined and its impacts on cell cycle progression and cyclin expression were investigated. EPA inhibited proliferation of K-562 cells, which was associated with accumulation of G0/G1 cells and down-regulation of cyclin E expression. Cyclin B1-expressing cells were also reduced showing that down-regulation of cyclin expression might be important in the anti-proliferation of EPA.
All Author(s) ListChiu LCM, Ooi VEC, Wan JMF
Journal nameInternational Journal of Oncology
Volume Number19
Issue Number4
Pages845 - 849
LanguagesEnglish-United Kingdom
Keywordsanti-proliferation; cyclin B1; cyclin E; eicosapentaenoic acid; flow cytometry
Web of Science Subject CategoriesOncology; ONCOLOGY

Last updated on 2021-14-09 at 00:32