Hygroscopic study of glucose, citric acid, and sorbitol using an electrodynamic balance: Comparison with UNIFAC predictions
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AbstractThe equilibrium water sorption and desorption characteristics of three pharmaceutical excipients, namely, glucose, citric acid, and sorbitol, were investigated at 25 degreesC using an electrodynamic balance (EDB). The mass fraction of solute (mfs), defined as the ratio of the dry solute mass to the solution mass, of the additives was measured as a function of relative humidity (RH) at equilibrium. Bulk measurements and literature data suggest that these three additives all crystallize at their respective saturation conditions. However, crystallization or deliquescence was not observed for the suspended particles of the three additives. They behave as nondeliquescent materials and sorb and desorb water reversibly. At RH = 5%, citric acid particles still contain similar to8 wt% residual water, which corresponds to a stoichiometry of citric acid monohydrate. Glucose and sorbitol particles are essentially water-free. Universal Functional Activity Coefficient (UNIFAC) model predicts the water activities of glucose, citric acid, and sorbitol (expressed as mfs of the particles) to within +/-16%, 24%, and 6% of those determined by the EDB, respectively.
All Author(s) ListPeng CG, Chow AHL, Chan CK
Journal nameAerosol Science and Technology
Year2001
Month9
Day1
Volume Number35
Issue Number3
PublisherTAYLOR & FRANCIS INC
Pages753 - 758
ISSN0278-6826
LanguagesEnglish-United Kingdom
Web of Science Subject CategoriesEngineering; Engineering, Chemical; ENGINEERING, CHEMICAL; Engineering, Mechanical; Environmental Sciences; ENVIRONMENTAL SCIENCES; Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences; METEOROLOGY & ATMOSPHERIC SCIENCES

Last updated on 2020-29-11 at 02:09