The anti-tumour effect of Klebsiella pneumoniae capsular polysaccharides
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摘要K24 capsular polysaccharide (K24-CPS), with a known structure of a repeating unit, was isolated from the capsule of Klebsiella pneumoniae serotype K24. The polysaccharide was found to suppress the proliferation of Ehrlich ascites tumour (EAT) cells in vitro, but did not alter the cell cycle distribution of cells. K24-CPS treatment reduced the tyrosine phosphorylation of some proteins in EAT cells. Furthermore, the treatment also decreased the expression of c-JUN, but had no effect on the levels of c-FOS and c-MYC. It is speculated that the growth suppression effect of K24-CPS may be related to its effect in down-regulating c-JUN expression. Copyright (C) 2001 S. Karger AG, Basel.
著者Kwok TT, Chen P, Liu PY, Tang YC, Kong SK, Fung KP, Choy YM
期刊名稱BIOLOGICAL SIGNALS AND RECEPTORS
出版年份2001
月份9
日期1
卷號10
期次5
出版社KARGER
頁次294 - 298
國際標準期刊號1422-4933
語言英式英語
關鍵詞C-JUN; Ehrlich ascites tumour cells; K24 capsular polysaccharide; protein tyrosine phosphorylation
Web of Science 學科類別Biochemistry & Molecular Biology; Biophysics; Cell Biology

上次更新時間 2020-04-08 於 02:54